Thesis: Design and Characterization of Virtual Microfluidic Channels for Organ-On-Chip Systems

In cooperation with the Chair of Laser Technology (LLT), the Fraunhofer Institute for Laser Technology (ILT)—Europe’s leading center for contract research and development in the field of laser technology—is offering the opportunity to write a master’s thesis on the topic: Design and Characterization of Virtual Microfluidic Channels Using UKP Laser Processing for Organ-on-a-Chip Systems.

The project is being carried out in close interdisciplinary collaboration with an RWTH research team in the field of biohybrid medicine and textiles (BioTex).

Research in this field focuses on the development of living, biohybrid implants with the potential for remodeling, regeneration, and self-repair. A key objective is to develop biotechnological solutions to meet clinical needs while also addressing the societal need to reduce animal testing in the biomedical research environment. Consequently, microfluidic organ-on-chip models for cultivating microphysiological organ models are becoming increasingly important. These complex in vitro biological models require specific structures, such as the integration of vertical membranes or the creation of virtual channels through hydrophobic and hydrophilic surface structures.

Such microscopic surface structures can be created, among other methods, using ultrashort-pulsed laser radiation. These structures are then transferred onto chips via subsequent casting processes. The aim of this work is to fabricate various surface structures in glass using USP, followed by casting, and to characterize the chips in terms of their microfluidic properties so that they can subsequently be used in initial cell culture tests.

Be part of change

• Your role involves the conceptualization, design, and characterization of microfluidic structures to create virtual channels in organ-on-a-chip systems
• You will independently plan and conduct experiments for the production of molds using UKP laser structuring
• The fabrication of microfluidic chips using the molds produced by laser processing and the characterization of the hydrophobic/hydrophilic regions
• Documenting and discussing the results is part of your responsibilities

What you contribute

• You’re studying mechanical engineering, material science, medical engineering, physics or a comparable field
• Interest in laser material processing and biomedicine in application-oriented research
• Independent, organized, and structured way of working
• Prior laboratory and laser experience is beneficial, but not required

What we offer

👥 Team spirit: Creative, interdisciplinary environment with a motivated team, flat hierarchies, and an informal culture.
🖥 Workplace: Excellent range of machines and equipment, as well as first-class office facilities.
💪 Involvement: Practice-oriented thesis in an innovative applied research environment.
🧘 Work-life balance: Benefit from flexible working hours based on trust.
🚐 Getting there: Good transport connections, parking spaces directly in front of the institute, an e-charging station, and a parking garage.

The position is limited in duration until completion of the thesis. We value and promote the diversity of our employees' skills and therefore welcome all applications – regardless of age, gender, nationality, ethnic and social origin, religion, ideology, disability, sexual orientation and identity. Severely disabled persons are given preference in the event of equal suitability. Our tasks are diverse and adaptable – for applicants with disabilities, we work together to find solutions that best promote their abilities.

With its focus on developing key technologies that are vital for the future and enabling the commercial utilization of this work by business and industry, Fraunhofer plays a central role in the innovation process. As a pioneer and catalyst for groundbreaking developments and scientific excellence, Fraunhofer helps shape society now and in the future. 

Ready for a change? Then apply now and make a difference! Once we have received your online application, you will receive an automatic confirmation of receipt. We will then get back to you as soon as possible and let you know what happens next.

If you have any questions about this position, please contact:

Lara Christina Ive Beckmann M. Sc.
Phone: +49 241/8906-410 

Fraunhofer Institute for Laser Technology ILT 

​" target="_blank" rel="noopener">www.ilt.fraunhofer.de 

Requisition Number: 84174                Application Deadline: 08/31/2026