Senior Director, Development Pharmacology & Toxicology

How You Will Achieve More:

The Senior Director of Development Pharmacology & Toxicology provides strategic leadership in establishing and executing pharmacology and toxicology strategies across multiple therapeutic platforms, including nucleic acid, lipid nanoparticle, cell therapy, small and large molecule. This role is accountable for delivering on substantial departmental goals with direct impact on program and corporate objectives. The Senior Director provides platform-level guidance for safety assessment approaches and oversees cross-functional teams to ensure regulatory success across multiple development programs.

Responsibilities:

• Establish and direct platform-wide testing strategies across therapeutic modalities, proactively anticipating evolving guidance from FDA, EMA, ICH and other agencies to create innovative approaches for gene editing, nucleic acid, lipid nanoparticle, and AAV products.
• Lead development of compliance frameworks for Good Laboratory Practice (GLP) across multiple programs; integrate GMP considerations into nonclinical testing strategies to ensure seamless transition from early to late development.
• Guide design and oversee successful execution of critical nonclinical studies, including pivotal GLP toxicology studies in support of program advancement into and through clinical development.
• Shape industry best practices through external engagement and influence regulatory thinking around novel therapeutic modalities, positioning the company as a thought leader in the evolving regulatory landscape.
• Direct preparation and review of comprehensive regulatory submission packages, making final determinations on nonclinical content strategy for INDs, CTAs, BLAs, and NDAs across multiple programs simultaneously.
• Lead cross-functional initiatives with research, clinical development, manufacturing, regulatory affairs, and quality assurance to develop integrated approaches that enhance overall program strategy beyond individual regulatory considerations.
• Define strategic integration between Discovery PharmTox and Development PharmTox to ensure cohesive pipeline progression and seamless candidate transition, establishing long-term nonclinical development frameworks.
• Establish departmental priorities and resource allocation strategies in partnership with Preclinical Operations leadership to optimize organizational capabilities across the portfolio.
• Represent the company in critical regulatory agency interactions, presenting strategic positions at senior levels and negotiating complex scientific and regulatory matters with health authorities globally.
• Direct due diligence activities for potential partnerships, in-licensing, or acquisition opportunities, making recommendations that inform corporate development strategy and long-term portfolio planning.
• Serve as a key member of the R&D leadership team, contributing to organizational strategy and assuming broader responsibilities for VP, Pharmacology & Toxicology in their absence or upon delegation.

Supervisory Responsibilities

• Recruits, interviews, hires, and trains new staff.
• Oversees the daily workflow of the department.
• Foster a culture of scientific excellence, innovation, and collaboration within the department and across the organization.
• Provides constructive and timely performance evaluations.
• Handles discipline and termination of employees in accordance with company policy.

About You:

• Comprehensive knowledge of IACUC, GLP, laboratory safety and data integrity standards to anticipate necessary resources
• Proficiency with Microsoft Word, Excel, Powerpoint, and MS Project
• Experience managing scientific projects in a highly matrixed organization; evidence of collaboration in multidisciplinary environment
• Experience managing rodent and large animal (e.g., non-human primate) studies
• BS, MS, PhD in pharmacology, toxicology or related field
• At least 15 years + BS, 12 yrs + MS, 10 yrs + PhD experience required.
• At least 7 years supervisory experience required
• Prolonged periods of sitting at a desk and working on a computer

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EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Applications are accepted on a rolling basis, and will continue to be accepted until the position is filled at which point the position will be taken down.

The salary offered is determined based on a range of factors including, but not limited to, relevant education and training, overall related experience, specialized, rare or in-demand skill sets, internal comparators and other business needs. Upon joining Intellia, your salary will be reviewed periodically and additional factors such as time in role and performance will be considered. Intellia may change the published salary range based on company and market factors.

Additional compensation includes a performance-based annual cash bonus, a new hire equity grant, and eligibility to be considered for annual equity awards the value of which are determined annually at the Company’s discretion.

For more information about Intellia’s benefits, please click here.