Sr. Clinical Trial Manager

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. 

Centessa is seeking to hire a Senior Clinical Trial Manager (Sr. CTM) to lead the execution of global clinical studies from startup through closeout and clinical study report. This role is a temporary position with the potential to convert to a permanent role, accountable for study delivery, including operational strategy, timelines, budget, quality, vendor oversight, risk management, and inspection readiness. This individual in this role will lead cross-functional teams and manage CROs and external vendors to ensure studies are conducted efficiently, compliantly, and in alignment with program objectives. 

Key Responsibilities

• Lead the planning, execution, and oversight of global clinical trials from startup through closeout. 
• Serve as the primary operational lead for assigned studies, driving cross-functional alignment and execution. 
• Develop and manage study timelines, budgets, enrollment forecasts, risk mitigation plans, and key performance metrics.  
• Oversee CROs and external vendors to ensure delivery against scope, quality standards, timelines, and budget.  
• Drive critical study milestones, including site activation, enrollment, database lock, and study closeout.  
• Review and approve study plans, vendor deliverables, and trial documentation to ensure compliance with protocol, GCP, and regulatory requirements.  
• Identify operational risks and issues, implement mitigation strategies, and escalate as appropriate. 
• Lead study team meetings and provide regular updates to stakeholders and senior management.  
• Ensure Trial Master File (TMF) quality, completeness, and inspection readiness throughout the study lifecycle. 
• Support regulatory submissions, audits, inspections, and Health Authority interactions.  
• Contribute to process improvements and mentor junior clinical operations team members as needed. 
• Collaborate effectively with global teams, investigators, CROs, and vendors across multiple regions.  

Qualifications

• Bachelor's degree in a scientific, health-related, or equivalent discipline required.
• 8+ years of clinical research experience, including 5+ years of clinical trial management experience within a sponsor or CRO environment.  2+ years of managing Phase 1 Healthy Volunteer studies.    
• Experience in standard clinical pharmacology package studies such as: First in Human, Drug to Drug Interaction, Human Absorption, Metabolism, Excretion and Mass Balance, Relative Bioavailability, Bioequivalence, Organ Impairment, Abuse Liability studies.  
• Demonstrated experience independently leading Phase 1 studies, global Phase II and/or Phase III clinical trials.
• Experience managing CROs, CRUs, central vendors, and cross-functional study teams.
• Neuroscience/CNS clinical development experience preferred.
• Experience supporting inspection readiness, audits, and regulatory interactions preferred.  

Compensation 

The annual base salary range for this position is $127,000.00 - $180,0000.00.Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge.  

In addition to base pay, this role is eligible for a discretionary annual bonus. The company also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision and life insurance, generous paid time off, and a health and wellness program.

Work Location

The Senior Clinical Trial Manager role is a based in the US (Remote), with occasional travel required. 

Position: Full-time, Exempt

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly