SeniorPrincipal Scientist Systems Toxicology (mfd)

Are you a highly talented and motivated Modelling & Simulation Scientist

with experience in the pharma, cosmetics, crop protection, flavoring, or chemistry industry? Do you enjoy driving innovation and setting new boundaries in System Toxicology and Risk Assessment? This position offers you this and more exciting work in an innovative and fastpaced environment.

ESQlabs is an innovative, internationally acting Contract Research Organization and a global leader in the development and application of the OSP Suite (www.opensystemspharmacology.org). We are a researchfocused provider of specialized computational analyses in the life sciences industry.

To help us grow our global PBKQST business, we are looking for a Senior Scientist Systems Toxicology (mfd) to strengthen our multidisciplinary project teams for the successful completion of client goals. This role will engage in activities ranging from consultations on study design and regulatory requirements through the development and evaluation of models, the performance of simulations, and the presentation of results.

Role

• Complement a dedicated highperforming team of scientists
• Collaborate with colleagues on multidisciplinary teams to implement quantitative modeling and simulation projectsprograms and to provide risk assessment and PBKQST consultation to other company projectsprograms
• Provide modeling and simulation consulting through advanced PBK, QST, and exposureresponse modeling and simulation using the OSPSuite (PKSim, MoBi, R), or other tools
• Support risk assessment protocols, study conduct, data analysis, and report writing with the support of colleagues
• Responsible for appropriateness of methods, integrity of data used for analysis, and accuracy of results
• Regularly engage with clients regarding the strategic approach, project execution, presentation of results, regulatory implications, and messaging of findings
• Prepare final technical reports, synopses, executive summaries, and other regulatory documents
• Ensure the provision of advanced literature searches for projectprogramrelated information
• Provide sophisticated written interpretation of material and integrate research findings into projectprogram methodology and results
• Share findings with internal and external project teams; prepare abstracts, presentations, and publicationready manuscripts
• Provide mentoring and feedback to junior scientists
• Integrate knowledge of PBK and QST to provide guidance regarding proposed approaches to address risk assessment and regulatory approval challenges
• Expand scientific expertise through attendance and presentation at international, national, and regional scientific conferences, client meetings, and government meetings
• Develop and teach at OSPSuite (PKSim, MoBi, R), and other workshops and courses

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  Required skills & experience

  • 5+ years (Principal 10+ years) of applied toxicology
    
  • 3+ years (Principal 5+ years) of leading projects and programs
  • 3+ years (Principal 5+ years) of experience in regulatory applications of PBK modeling
  • Good knowledge of regulatory requirements and guidelines for PBK and QST
  • Strong experience presenting scientific results to professional audiences
  • Extensive experience preparing, submitting, and receiving approval for publications in scientific journals
  • Mechanistic physiologically based kinetic modeling and simulation experience
  • Expert knowledge in domainspecific modeling software (e.g. PKSim® MoBi®, SimCyp®, or GastroPlus® or TKplate)
  • Excellent communication, presentation, and leadership skills
  • Relationshipbuilding skills with the ability to work closely with project leaders and team members
  • Strong organization skills and ability to handle multiple tasks simultaneously
  • Work well handling tight deadlines
  • Great criticalthinking and problemsolving skills
  • Fluency in English (oral and written), German is a plus

  • Education

    • PhD, or masters in quantitative sciences (Bioengineering, Applied Math, ...) with advanced toxicology related training
    • Or PharmD or PhD in pharmacology, toxicology, or related field with advanced applied mathematics related training

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      Further qualities that will put you in the spotlight
      

      • Experience in regulatory submissions
      • Advanced expertise in kinetics modeling software (e.g. NONMEM®, Monolix, or IQRtools)
      • Proficiency in a scripting language for modeling and simulation (ideally R, alternatively MATLAB®)
      • A strong understanding of statistics
      • Strategic domain knowledge: Drug development, Crop protection, Flavoring, etc
      • Published peerreviewed articles

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        Whats in store for you
        

        The dynamic team behind esqLABS unites people with different backgrounds, spanning disciplines like pharmaceutical sciences, physics, bioinformatics, mathematics, data science, and software engineering. Our trust in each other, our openmindedness, and our constant quest for excellence and innovation unite us. We value flat hierarchies, where everyone can contribute ideas and expertise to develop the best product. We are passionate, always willing to broaden our horizons, and love our startup culture.

        You will also benefit from:

        • Flexible work hours and a home office policy that focuses on people and not on numbers
        • An attractive remuneration package
        • A dedicated budget for education programs and conferences you can attend
        • A working environment in which your contribution will make a difference, and that allows you to take ownership of projects and processes
        • Responsibility, autonomy, participation, and career perspective

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          About us

          We collaborate with global corporations in the pharma and chemical industry, as well as startups in the lifescience technology sector and academic and nonprofit research institutions. We define new standards in pharmacometrics and systems pharmacology and toxicology areas. Our software and model platforms help scientists understand mechanisms of diseases and chemical toxicity to optimize individualized treatment of patients and protect the health of the animal and human life.

          ESQlabs has attracted international players as sponsors for the OSP Software development. In addition, funding through national and EUwide research grants allows us to develop our core technologies continuously.

          For more information about our culture, values and benefits visit our Unique career opportunities ESQlabs GmbH.

          At ESQlabs, we are committed to diverse backgrounds and experiences.