Logo for Twin Health

Principal Product Manager, Core AI

Role overview

Qualifications

  • 8+ years in Product Management (or equivalent impact), including significant experience building AI-native products
  • 3+ years building and shipping products powered by LLMs, Agents, RAG, Personalization systems
  • Track record of owning complex, system-level products
  • Experience shipping conversational or voice experiences with measurable impact

Responsibilities

  • Define the Digital Twin intelligence system
  • Build specialized agent systems such as sensor intelligence, scheduling, and coordination
  • Define next-generation conversational experiences across chat and voice
  • Establish metrics and evaluation systems for guidance quality and conversation effectiveness

Key facts

Other skills

  • Analytical Skills
  • Problem Solving

About the company

Twin Health logo

Twin Health

Digital Health & Health Tech

At Twin, we combine advanced medical science with digital twin technology to help people reverse, improve, and prevent chronic metabolic diseases like type 2 diabetes, pre-diabetes, and heart disease. We do it by helping each Twin member improve their metabolic fitness. Our truly precise and personalized approach makes us a service like no other. Our passion and dedication make us a team like no other. The pillars of the Twin Service are our Whole Body Digital TwinTM and dedicated care team; together, they provide each member with individualized attention throughout their healthy journey. Each member’s Digital Twin utilizes wearable health technology to build a dynamic digitalization of their unique metabolism. Our members receive daily guidance from their Twin, and as their metabolism heals, their Twin continues to learn — allowing them to introduce new foods and activities. These daily insights help our members sustain a healthy life, personalized to them. This high-tech precision is supported by a dedicated care team of doctors, nurses, dietitians, and health coaches who provide support, education, and guidance for members throughout their journey. Each person who works on the Twin team shares a mission-driven mentality and interest in helping people. As our team grows, we hold ourselves accountable to a work-life balance that puts us in the best position to help our members.

Company details

Company typeScaleup
IndustryDigital Health & Health Tech
Company size201 - 500

Your match analysis

See how your profile stacks up against this role.

We compared the job requirements to your profile to show where you're strong and where you fall short.

Job description

Twin Health 

At Twin Health, we empower people to improve and prevent chronic metabolic diseases, like type 2 diabetes and obesity, with a new standard of care. Twin Health is the only company applying AI Digital Twin technology exclusively toward metabolic health. 

We start by building a dynamic model of each person’s metabolism — drawing on thousands of data points from CGMs, smartwatches, and meal logs — that maps their personal path to better health. Guided by a dedicated clinical care team, our members have lowered their A1C below the diabetes range, achieved lasting weight loss, and reduced or even eliminated medications, all while living healthier, happier lives.

Working here 

Our team at Twin Health is passionate, talented, and united by a shared purpose: to improve the metabolic health and happiness of our members. We believe in empowering every Twin to make a meaningful impact for our members, our clients, and each other, while enjoying a supportive, collaborative work environment.

Twin has been recognized not only for our innovation but also for our culture, including: Innovator of the Year by the Employer Health Innovation Roundtable (EHIR), selected to CB Insights’ Digital Health 150, and named one of Newsweek’s Top Most Loved Workplace® .

With more than $100 million raised in recent funding, including a $53 million Series E round in 2025 led by Maj Invest, and a $50 million investment in 2023 led by Temasek, Twin is scaling rapidly across the U.S. and globally. Backed by leading venture firms like ICONIQ Growth, Sequoia, Sofina, Temasek, and Peak XV, we are building the most impactful digital health company in the world.

Join us as we reinvent the standard of care in metabolic health.

Opportunity

We are building a new interface to health: the Digital Twin.

The Digital Twin is a living, real-time model of each member’s metabolism and behavior—continuously learning from sensors, meals, sleep, movement, labs, and daily choices. It detects patterns, anticipates what’s coming, and guides members toward better health through timely, personalized actions.

To the member, it feels like a single, ever-present guide.

Under the hood, it’s a coordinated system of AI agents and human care working as one.

We’re looking for a Principal Product Manager to help define and build the core intelligence system at the heart of Twin.

This role sits at the intersection of:

  • LLMs and agent systems
  • Human + AI orchestration
  • Real-time health guidance
  • Voice and conversational interfaces
  • Platform and developer ecosystems

You will:

  • Define how the Digital Twin behaves across text, voice, and proactive experiences
  • Build specialized sub-agents that plug into the core Digital Twin
  • Create the platform and primitives that enable teams across Twin to build agents safely and quickly
  • Push the boundaries of what’s possible with modern AI systems in healthcare

Responsibilities 

  • Define the Digital Twin intelligence system
    • Translate the core loop—Sense → Understand → Decide → Act → Learn—into a scalable agent system
    • Define how the Digital Twin reasons, responds, escalates, and coordinates across experiences
    • Shape the future of AI-driven health guidance across text, voice, and proactive interactions
  • Build specialized agent systems
  • Sensor intelligence
  • Scheduling and coordination
  • Nutrition
  • Exercise, sleep, and stress
  • Insights
  • App help and operational support
  • Care-team interaction orchestration
  • Build the platform that enables the company
  • Create the foundations that allow PMs and teams to build on top of the Digital Twin
  • Establish primitives for:
    • Agent creation and orchestration
    • Memory and personalization
    • Evaluation and monitoring
  • Define next-generation conversational experiences
    • Build deeply personalized experiences across chat, two-way voice, and ambient guidance
    • Define conversation patterns and interaction models that feel natural, trusted, and useful
  • Operate at frontier speed
    • Rapidly move from insight → prototype → experiment → production
    • Partner deeply with AI Engineering, Design, Clinical, and Product teams
    • Continuously evaluate emerging capabilities across LLMs, speech, memory, and agent systems
  • Establish metrics and evaluation systems for:
    • Guidance quality
    • Conversation effectiveness
    • Problem resolution
    • Behavior change
  • Other duties as assigned.

Qualifications 

  • 8+ years in Product Management (or equivalent impact), including significant experience building AI-native products
  • 3+ years building and shipping products powered by:
    • LLMs
    • Agents
    • RAG
    • Personalization systems
  • Track record of owning complex, system-level products
  • Experience shipping conversational or voice experiences with measurable impact
  • Strong product judgment and analytical instincts:
    • Experimentation
    • Evaluation design
    • KPI definition
  • Builder mindset—you move from concept to shipped system quickly

Compensation and Benefits 

The compensation range for this position is $205,000 - $240,000 annually. 

Twin has an ambitious vision to empower people to live healthier and happier lives, and to achieve this purpose, we need the very best people to enhance our cutting-edge technology and medical science, deliver the best possible care, and turn our passion into value for our members, partners and investors. We are committed to delivering an outstanding culture and experience for every Twin employee through a company based on the values of passion, talent, and trust. We offer comprehensive benefits and perks in line with these principles, as well as a high level of flexibility for every Twin

  • A competitive compensation package in line with leading technology companies
  • A remote and accomplished global team
  • Opportunity for equity participation 
  • Unlimited vacation with manager approval
  • 16 weeks of 100% paid parental leave for delivering parents; 8 weeks of 100% paid parental leave for non-delivering parents
  • 100% Employer sponsored healthcare, dental, and vision for you, and 80% coverage for your family; Health Savings Account and Flexible Spending Account options
  • 401k retirement savings plan
Salary range for US jobs
US Salary Range
$205,000$240,000 USD

We have been made aware of fraudulent interview requests being sent using the Twin Health's name. All communications will come from official Twin Health channels and a twinhealth.com email address. We will never ask you to complete a text interview or request financial details during the interview process. 

Apply once. Then go straight to the hiring manager.

After you apply, unlock the direct contact details of the people who actually make the call. A quick follow-up makes you 5x more likely to land an interview.

MR

Marcus Rivera

Chief Revenue Officer

m.rivera@company.com
linkedin.com/in/marcusrivera
Unlocked after you apply
·

Product Manager (Tech) Related jobs

Other jobs at Twin Health

Premium

Reach out to the hiring manager directly.

Gain access to the contact details of the hiring managers who actually decide, and reach out to network with them directly. That, plus more when you upgrade:

  • Full match report with fit score and gaps
  • Career diagnostics on how recruiters read you
  • Curated company matches and warm intros
  • 48h early access to new roles

Cancel anytime.