Horizon
Biotechnology
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At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Let’s do this. Let’s change the world. In this vital role you will
have an opportunity to be a hands-on architecture leader within the Applied AI – AI Productivity and Custom GPT Solutions Practice. The role defines and guides secure, scalable, reusable, and production-ready GenAI solutions that enable Amgen organizations to adopt LLM-powered assistants, agents, Custom GPTs, and AI-enabled applications.
This role translates business needs into end-to-end technical designs, establishes reference architectures and guardrails, validates critical concepts through targeted prototypes, and guides engineering teams from solution discovery through production deployment and operational handover.
RESPONSIBILITIES
GenAI Solution Architecture
Lead end-to-end architecture for LLM-powered assistants, agents, Custom GPTs, RAG solutions, and AI-enabled applications across experience, model, retrieval, orchestration, integration, security, cloud, deployment, and observability layers.
Translate functional and non-functional use case requirements into architecture documents, diagrams, integration patterns, data flows, security models, deployment designs, and implementation guidance.
Select appropriate patterns, including prompt engineering, RAG, agentic orchestration, workflow automation, traditional software logic, or model customization—based on quality, risk, scalability, latency, cost, and supportability.
Architect solutions using ChatGPT Enterprise, MCP-based apps, ChatGPT Skills, enterprise APIs, Databricks, vector search, governed data sources, and approved AI platforms.
Design agentic and event-driven solutions using OpenAI SDKs, LangChain/LangGraph, n8n, APIs, webhooks, and human-in-the-loop controls.
Develop targeted proofs of concept and reference implementations to validate architecture decisions, reduce delivery risk, and accelerate engineering execution.
Guide delivery teams through implementation and ensure delivered solutions remain aligned with approved architecture, security controls, engineering standards, and operational requirements.
Architecture Governance, Security, and Operations
Conduct solution and architecture reviews; identify technical risks, platform constraints, security gaps, data-governance concerns, and operational dependencies; and document decisions, assumptions, tradeoffs, and recommendations.
Establish reusable reference architectures, solution patterns, technical standards, guardrails, and architecture decision records for enterprise GenAI adoption.
Define non-functional requirements covering privacy, security, responsible AI, performance, scalability, observability, auditability, maintainability, and total cost of ownership.
Define safeguards for prompt injection, data leakage, unauthorized retrieval, insecure tool execution, excessive agency, secrets exposure, and inappropriate model outputs, including appropriate human oversight for high-risk actions.
Establish secure identity and access patterns using OAuth, service identities, delegated authorization, role-based access control, secrets management, least privilege, and user-level auditability.
Define evaluation, regression-testing, red-teaming, tracing, monitoring, deployment, rollback, incident-management, and operational-readiness approaches for production GenAI systems.
Platform Strategy and Technical Leadership
Evaluate emerging AI platforms and technologies and contribute to the GenAI capability roadmap by identifying platform gaps, reusable services, standard integrations, and strategic architecture improvements.
Partner with product owners, business leaders, engineering, data, platform, DevOps, cybersecurity, privacy, responsible AI, and enterprise architecture teams to move solutions from concept to production.
Facilitate architecture workshops and communicate technical options, tradeoffs, dependencies, risks, and recommendations to technical teams and senior stakeholders.
Provide technical leadership across multiple GenAI initiatives, mentor engineers and solution designers, and support architecture consultations, design clinics, and technical office hours.
Produce concise architecture documents, technical specifications, implementation guidance, runbooks, and handover materials that support long-term operational sustainability.
We are all different, yet we all use our unique contributions to serve patients. The professional we seek is an architect with these qualifications.
Basic Qualifications
Master’s degree with 6 or more years of relevant experience in Computer Science, Information Technology, Engineering, Data Science, or a related field; or
Bachelor’s degree with 8 or more years of relevant experience in Computer Science, Information Technology, Engineering, Data Science, or a related field.
6 or more years of progressive experience in software engineering, system design, cloud architecture, or solution architecture, including at least 2 years leading end-to-end technical design or serving as a lead engineer, technical architect, or solution architect.
2 or more years of hands-on experience architecting and delivering production GenAI applications, assistants, agents, Custom GPTs, or RAG solutions on ChatGPT Enterprise or comparable enterprise AI platforms.
Strong knowledge of GenAI solution architecture, including model selection, prompt and context design, RAG, embeddings, vector and hybrid retrieval, agent orchestration, tool integration, evaluation, guardrails, observability, and cost optimization.
Demonstrated experience defining end-to-end architectures across application, AI, data, integration, security, cloud, deployment, and operational layers.
Demonstrated experience architecting secure, scalable, and production-ready solutions on AWS, using managed AI services and cloud-native compute patterns such as AWS Lambda, Amazon ECS on AWS Fargate, and Amazon EC2, with strong knowledge of IAM, VPC networking, API Gateway, event-driven integration, observability, resiliency, and cost optimization.
Experience designing secure enterprise integrations using REST APIs, event-driven patterns, OAuth, service identities, role-based access control, secrets management, and least-privilege access.
Strong hands-on proficiency in Python and experience developing prototypes, reference implementations, APIs, evaluation utilities, or integration components for GenAI solutions.
Experience conducting architecture reviews, creating architecture artifacts, documenting decisions and tradeoffs, defining nonfunctional requirements, and guiding engineering teams through implementation.
Ability to communicate complex technical recommendations clearly to engineers, product owners, platform teams, business stakeholders, and senior leaders.
Preferred Skills
Experience with ChatGPT Enterprise, OpenAI APIs and SDKs, MCP servers and apps, ChatGPT Skills, LangChain, LangGraph, n8n, or comparable agent technologies.
Hands-on experience with Amazon Bedrock, related agent capabilities, and other AWS AI services.
Experience with Databricks, Unity Catalog, Vector Search, SQL Warehouses, semantic layers, or governed natural-language-to-SQL solutions.
Working knowledge of modern web application architecture using TypeScript, React, Next.js, API-driven user experiences, automated testing, and CI/CD practices.
Experience with responsible AI, threat modeling, AI security, model governance, GxP, computer-system validation, or other regulated technology environments.
Relevant cloud, architecture, security, data, or AI certifications.
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
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