Director, HEOR Therapeutic Area Lead (Acromegaly)

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.

Position Summary:

The Director, HEOR/RWE Therapeutic Area (TA) Lead — Paltusotine (Acromegaly) is the stakeholder-facing HEOR/RWE owner for the acromegaly franchise. As Crinetics' lead product, PALSONIFY™ (paltusotine), moves through launch and lifecycle management in acromegaly, this role defines the therapeutic-area evidence strategy — the value story, evidence gaps, and HEOR/RWE priorities — and partners with Medical Affairs, Market Access, Commercial, Clinical Development, and Patient Advocacy to anchor that evidence to launch, access, and lifecycle decisions. The TA Lead does not execute studies directly; working with the Senior Director, Paltusotine Program, the Director translates acromegaly evidence questions into prioritized plans and directs the HEOR/RWE Centers of Excellence (RWE, PRO/COA, Modeling & Simulation, Advanced Analytics) to deliver them. This role is accountable for a coherent, payer-, HTA-, and access-ready value story for acromegaly across the product lifecycle. Reporting to the Senior Director, HEOR/RWE Head of the Paltusotine Program, the Director runs the acromegaly indication in consistency with the overall Paltusotine value story.

Essential Job Functions and Responsibilities:

These may include but are not limited to:

• Own the acromegaly HEOR/RWE evidence strategy across the product lifecycle — define the value narrative, identify evidence gaps, and set TA-level evidence priorities for PALSONIFY (paltusotine).
• Serve as the primary HEOR/RWE point of contact for acromegaly franchise stakeholders — Medical Affairs, Market Access, Commercial, Clinical Development, Patient Advocacy, and regional/affiliate teams.
• Translate franchise evidence questions into prioritized, executable plans and commission delivery through the HEOR/RWE Centers of Excellence (RWE, PRO/COA, Modeling & Simulation, Advanced Analytics).
• Contribute the acromegaly HEOR/RWE narrative to integrated evidence plans, value dossiers, AMCP and global value dossiers, and HTA submissions.
• Partner with Market Access on payer value propositions, budget impact, and access strategy for acromegaly.
• Align acromegaly evidence generation to launch, access, and lifecycle milestones; anticipate evidence needs ahead of Phase III and regulatory windows.
• Represent the acromegaly evidence story to KOLs, payers, HTA bodies, and at scientific congresses.
• Support the Senior Director, Paltusotine Program in maintaining a coherent franchise value story, coordinating with the carcinoid syndrome lead across indications.
• Monitor the competitive and treatment landscape in acromegaly and translate implications into evidence strategy.
• Ensure compliance with corporate policies and US healthcare laws governing evidence generation and communication.
• Other duties as assigned.

Education and Experience:

Required:

• Advanced degree in health economics, outcomes research, epidemiology, health services research, public health, or related discipline (PhD, MD, PharmD, MPH, MSc).
• Minimum of 10+ years of relevant pharmaceutical, biotech, or HEOR consulting experience.
• Minimum of 8+ years of supervisory years of experience.
• Equivalent combination of education and applicable job experience may be considered.
• Demonstrated ability to define and drive a therapeutic-area evidence strategy across the product lifecycle (pre-launch through lifecycle management).
• Strong stakeholder management and influencing skills, with a track record of partnering with Medical Affairs, Market Access, and Commercial.
• Working knowledge across the HEOR/RWE toolkit — RWE, PRO/COA, economic modeling, and HTA evidence requirements — sufficient to commission and quality-check work delivered by Centers of Excellence.
• Experience contributing HEOR evidence to value dossiers and HTA/payer submissions.
• Excellent communication and interpersonal skills, with the ability to influence senior business leaders across functions and geographies.
• Ability to lead, collaborate, and influence cross-functional teams.
• Ability to ensure compliance with corporate policies and procedures, as well as US healthcare laws and regulations.
• Flexible, adaptable, and able to operate effectively in ambiguity within a fast-scaling pipeline.

Preferred:

• Experience in rare or specialty endocrine, or other niche-population therapeutic areas.
• Acromegaly, neuroendocrine, or related specialty experience.
• Familiarity with launch and lifecycle HEOR for a recently launched product.

Physical Demands and Work Environment:

Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.

Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply.

Travel:

You may be required to travel for up to 5% of your time.

The Anticipated Base Salary Range: 

In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process.

Equal Opportunity Employer:

Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws.

Salary Range

The salary range for this position is: $196000 - $245000.

In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.