Syneos Health® is a leading fully-integrated life sciences services organization built to accelerate customer success. We partner with innovators at every point across the drug development and commercialization continuum, helping them navigate complexity, anticipate change and accelerate progress.
Our Clinical Solutions team members act with a drug development mindset, applying their years of experience and deep expertise to truly understand customer needs and represent those in the solutions we shape.
Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you’ll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to deliver – for one another, our customers, and, most importantly, for those in need.
Discover what your 25,000 future colleagues already know:
Why Syneos Health
• We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
• We are committed to building an inclusive culture – where you can authentically be yourself. Central to this is our purpose – Driven to Deliver – which captures the passion of our colleagues to show up each day and shape solutions that have the ability to dramatically impact someone’s life.
• We are continuously building the company we all want to work for and our customers want to work with. Why? Because we know that when we bring together smart colleagues from across the world, we can shape the future of healthcare, driving impact for customers and defining the pace of patient progress.
Job Responsibilities
This is a high-visibility opportunity for outstanding Site Activation Managers ready to step into a more strategic, sponsor-facing role within an FSP model. You’ll lead global site activation efforts while helping shape processes in a fast-evolving environment.
End-to-End SSU Leadership
Drive global site start-up strategy and execution from site identification through activation and lifecycle maintenance
Own SSU timelines, forecasts, and delivery against contracted milestones
Identify risks early (regulatory, enrollment, timelines) and implement mitigation plans
Operational Oversight
Lead all start-up deliverables, including:
Site identification and feasibility
Regulatory submissions and lifecycle maintenance (amendments, HA/EC communications, licenses)
CTA and investigator budget negotiation/execution
Essential document collection and TMF readiness
Ensure delivery aligns with SOPs, sponsor expectations, and quality standards
Sponsor & Cross-Functional Engagement
Act as a key interface with sponsor stakeholders, presenting strategy, risks, and status
Partner across Clinical Ops, PM, Contracts, Data Management, Medical Writing, and SSU Country teams
Collaborate within a team-first, highly accountable FSP environment
Financial & Scope Accountability
Review SSU budgets vs. milestones and support profitability targets
Track and manage out-of-scope activities in partnership with PM/SSU leadership
Regulatory Leadership
Oversee preparation of core submission documents and amendment dossiers
Conduct Regulatory Impact Assessments and communicate risks
Support development of SIS/ICF documents and country-specific submissions
Process & Build Mindset
Contribute to process creation and refinement as the team scales
Operate effectively in a setting where execution and process development happen in parallel
Minimum 3 years prior experience as a Site Activation Manager (SAM).
Minimum of 2 years' experience in Managing large scale, US-based Site Activation with high success.
Strong track record delivering SSU activities across Phase II–IV trials
Solid understanding of ICH-GCP, regulatory pathways, and start-up processes
Demonstrated ability to manage multiple studies and competing priorities
Strong communication, stakeholder management, and problem-solving skills
Highly Preferred
FSP (Functional Service Provider) experience
Prior Global SAM responsibility (regional experience considered with strong performance, if US based sites.)
Experience integrating Syneos and sponsor systems
Proven ability to operate in ambiguity and help build processes while delivering
Track record of high performance and readiness for increased scope/visibility
You’re known for staying focused and effective in fast-paced, evolving environments, consistently delivering strong results.
You are proactive, vocal, and solutions-oriented in a collaborative team environment
You balance execution excellence with strategic thinking
You elevate team performance while maintaining strong sponsor relationships
At Syneos Health, we believe in providing an environment and culture in which Our People can thrive, develop and advance. We reward and recognize our people by providing valuable benefits and a quality-of-life balance. The benefits for this position may include a company car or car allowance, Health benefits to include Medical, Dental and Vision, Company match 401k, eligibility to participate in Employee Stock Purchase Plan, Eligibility to earn commissions/bonus based on company and individual performance, and flexible paid time off (PTO) and sick time. Because certain states and municipalities have regulated paid sick time requirements, eligibility for paid sick time may vary depending on where you work. Syneos complies with all applicable federal, state, and municipal paid sick time requirements.
Salary Range:
The base salary range represents the anticipated low and high of the Syneos Health range for this position. Actual salary will vary based on various factors such as the candidate’s qualifications, skills, competencies, and proficiency for the role.
Get to know Syneos Health
Over the past 5 years, we have worked with 94% of all Novel FDA Approved Drugs, 95% of EMA Authorized Products and over 200 Studies across 73,000 Sites and 675,000+ Trial patients.
No matter what your role is, you’ll take the initiative and challenge the status quo with us in a highly competitive and ever-changing environment. Learn more about Syneos Health.
Additional Information
Tasks, duties, and responsibilities as listed in this job description are not exhaustive. The Company, at its sole discretion and with no prior notice, may assign other tasks, duties, and job responsibilities. Equivalent experience, skills, and/or education will also be considered so qualifications of incumbents may differ from those listed in the Job Description. The Company, at its sole discretion, will determine what constitutes as equivalent to the qualifications described above. Further, nothing contained herein should be construed to create an employment contract. Occasionally, required skills/experiences for jobs are expressed in brief terms. Any language contained herein is intended to fully comply with all obligations imposed by the legislation of each country in which it operates, including the implementation of the EU Equality Directive, in relation to the recruitment and employment of its employees. The Company is committed to compliance with the Americans with Disabilities Act, including the provision of reasonable accommodations, when appropriate, to assist employees or applicants to perform the essential functions of the job.
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