Director, Bioinformatics Engineering

GeneDx (Nasdaq: WGS) delivers personalized and actionable health insights to inform diagnosis, direct treatment, and improve drug discovery. The company is uniquely positioned to accelerate the use of genomic and large-scale clinical information to enable precision medicine as the standard of care. GeneDx is at the forefront of transforming healthcare through its industry-leading exome and genome testing and interpretation services, fueled by the world’s largest, rare disease data sets. For more information, please visit www.genedx.com.

The mission of the Innovation Lab is to increase the diagnostic yield of our exome and genome products and reduce the time to diagnosis for patients with undiagnosed hereditary disease. Our vision is to deliver personalized and actionable health insights to every person who orders a genetic test from GeneDx. Achievement of our goals will require a culture of innovation, where creativity, experimentation, and the pursuit of new ideas are encouraged and embraced. Individuals are empowered to think critically, take risks, and challenge the status quo to generate breakthrough solutions and drive positive change.

Summary

We are seeking a highly skilled and experienced Bioinformatics Engineer to join our dynamic team. The ideal candidate will have a strong background in bioinformatics, computational biology, and/or software engineering. This role involves leading bioinformatics projects, developing innovative computational methods, and collaborating with cross-functional teams to advance our research and development goals. 

Key Responsibilities

• Develop robust bioinformatics tools and workflows to support internal research, innovation, and continuous improvement in clinical genetics.
• Collaborate closely with interdisciplinary teams (bioinformatics scientists, software developers, clinical geneticists) to translate research pipelines into scalable, production-ready solutions.
• Actively participate in the full lifecycle of bioinformatics tools—from design and development to testing, documentation, deployment, and ongoing maintenance.
• Ensure developed solutions are reliable, maintainable, and meet production-quality standards to facilitate smooth transitions to our development and production teams.
• Maintain and support bioinformatics infrastructure, tools, and workflows.
• Provide guidance and mentorship to junior bioinformatics scientists and other team members.

Education, Experience, and Skills:

• Advanced degree (Ph.D. preferred) in Bioinformatics, Computational Biology, Genetics, Computer Science, or a related field.
• Minimum of 5 years of postdoctoral or industry experience in bioinformatics or computational biology.
• Extensive experience programming in Python, with a strong emphasis on software engineering best practices.
• Proven expertise developing and deploying bioinformatics workflows, preferably with experience in Nextflow or other workflow management frameworks (Snakemake, WDL, CWL).
• Comfortable working with cloud (OCI, AWS) and HPC environments, including containerization technologies like Docker.
• Proficiency working with databases, APIs, and web services.
• Prior experience in clinical genetics or genomic diagnostics is strongly preferred.
• Demonstrated ability to independently manage complex projects and deliver production-grade software.
• Preferred: Deep expertise in developing automated testing frameworks, including unit testing, end-to-end (E2E) testing, and clinical benchmarking, with a thoughtful philosophy and demonstrated experience around benchmarking pipeline performance and accuracy.
• Preferred: Experience in maintaining bioinformatics tools within regulated or clinical settings, coupled with a strategic mindset and a keen sense of product vision to drive broader organizational goals.

Certificates, Licenses, Registrations: N/A

• None

Physical Demands: 

• Ability to stand, walk, and sit for extended periods.

Work Environment:

• Fully remote.