Vice President, Translational Data Science/Computational Biology

Recursion's Platform

The Recursion OS is our platform for the industrialization of drug discovery, linking digital and physical workflows to automate therapeutic program initiation and optimization in a scaled, data-driven manner. These workflows automatically validate biological insights from high-dimensional in vitro profiling and optimize chemical matter through loops of experimental data, ML predictions, and are powered by patient datasets and Recursion’s “maps of biology” – a unique system integrating genome-scale reverse genetics and chemical profiling in a high-dimensional, uniform biological assay to predict trillions of relationships between biological perturbations and therapeutic candidates.

As the Vice President, Translational Data Science you’ll set the strategy and drive the implementation of connecting data from our genome-scale -omics platforms with population- and patient-derived genetics in the real world and leverage advanced analytics including ML/data science to identify and validate target selection, the right disease and patient linkages to our -omics phenotypes, and driving precision medicine via the development of translational biomarkers and patient selection to advance our therapeutic programs. In this role, you will:

• Lead the strategy and execution to industrialize the process of identifying diseases and patient populations through novel gene-compound inferences informed by population-scale forward genetics and genome-scale reverse genetics data 
• Integrate advanced machine learning methods to connect genetic insights across monogenic and polygenic conditions, ensuring that these discoveries are translated into actionable strategies for patient stratification, clinical trial design, and regulatory engagement across the entire drug development lifecycle

• Lead the strategy and implementation efforts to identify optimal disease and patient linkages to our -omics phenotypes, along with the discovery and validation of translational biomarkers and patient selection solutions to drive precision medicine for our therapeutic programs
• Drive the development and implementation of new computational tools including ML/DS approaches, algorithms, and methodologies
• Drive the integration of patient genetic and biomarker data collected in Recursion’s clinical trials to enable reverse translation, bridging clinical insights back into discovery programs. Be a key member to contribute to strategy for data and diagnostic partnerships in support of the Recursion OS and clinical portfolio
• Collaborate closely with leaders in discovery biology, chemistry, and clinical sciences to accelerate the translation of data-driven insights into tangible therapeutic advancements
• Establish strong cross-functional partnerships to ensure that computational biology efforts are deeply integrated into the therapeutic area strategies
• Guide teams of computational biologists and data scientists in executing the above strategy to industrialize the process of turning maps into medicines 
• Recruit, mentor, and manage high-performing teams of computational biologists and data scientists working in our therapeutic areas (oncology, neuroscience, and more) as well as on pan-therapeutic area initiatives, including genetics work

Success in this role will be primarily defined by the impact you show on the industrialization of program initiation with translatable genetic/genomic insights, and of program progression to the development with defined, validated biomarker strategies in clinical development. Success will be defined by the delivery from and development of the therapeutic area computational teams reporting to you.

The Team You’ll Join 

As the VP, Translational Data Science/Computational Biology, you will report to the SVP Clinical Development & Data Science, joining a diverse leadership team spanning research, development, data science, machine learning, computational chemistry, and computational biology across Recursion. You will collaborate with peer leaders in data science, biology, chemistry, and engineering to drive both present execution and future industrialization in both Recursion’s core therapeutic areas of oncology, neuroscience and future areas. 

The Experience You’ll Need

• 7+ years applying expertise in computational biology leveraging the latest techniques in ML across drug discovery and development. Key areas of prior experience include addressing  problems in functional and statistical genetics with high-dimensional -omics data, particularly aimed at problems in target identification, mechanistic fine-mapping, as well as  biomarker identification and development in precision medicine to enable  patient stratification and response prediction
• A track-record for pairing large-scale patient/population datasets in a closed loop with high-throughput in vitro functional genomics and machine learning to transform the process of identifying targets, models, and biomarkers with patient connectivity and validity
• Experience in developing and implementing patient stratification / precision medicine solutions in clinical development leveraging multi-omics and clinical data and well versed in regulatory considerations
• Experience hiring, managing, and mentoring multiple teams engaged in drug discovery activities in a matrixed environment
• Curiosity and the professional skill-set to excel in an open, highly collaborative, and growth-oriented environment

Location:

Making one of our offices your home base is preferred – London, New York City, or Salt Lake City  – however, we are open to remote work for this position. We ask that remote employees commit to regular on-site visits (~50% travel) for routine work and departmental events.

How You’ll be Supported

At Recursion, we’re working to solve some of the most meaningful challenges in human health. During onboarding, you’ll be introduced to the Recursion Mindset and Recursion OS through a blend of in-person and online resources designed to help you quickly embrace our culture. You’ll be paired with an onboarding "Trail Guide" to support you in your first months and connect with colleagues, both in person and remotely, who will guide you through the traditional and Recursion-specific aspects of your role. Additionally, you’ll join onboarding events, like Decoding Recursion, to deepen your understanding and integration into the team.

#LI-LM1

At Recursion, we believe that every employee should be compensated fairly. Based on the skill and level of experience required for this role, the estimated current annual base range for this role is:

• Developing: £220,000
• Skilled: £243,000
• Expert: £268,000

To learn more about our level within levels, click here.

You will also be eligible for bonuses and equity compensation + our comprehensive benefits package for United States based candidates. The range displayed on each job posting reflects target ranges for US new hire salaries and is determined by job, level, and market factors.  

During the interview selection process, you will connect with a Talent Acquisition Partner who will be your advocate and ally to ensure you receive the appropriate compensation that meets your needs for your skills, experience, and relevant education/training, while also reviewing our very competitive total rewards package.