Senior Scientist, Clinical Immuno-Oncology

Position: Senior Scientist, Clinical Immuno-Oncology, Early Oncology

Location: Cambridge, UK

Competitive Salary & Excellent Company Benefits

Follow the Science to Pioneer New Frontiers

Be part of the team that follows the science to transform the lives of cancer patients. As part of Early Oncology Research and Development, you will be a member of a team of professionals who are pioneering new frontiers by identifying and treating patients earlier while working toward the aim of eliminating cancer. We are driven by curiosity and backed by billions of investment pounds, we are empowered at every level to follow the science in pioneering new frontiers, exploring the most complex Oncology challenges to deliver new molecular entities over and over again. AstraZeneca’s pipeline is one of the broadest and deepest in the industry. Why don’t you consider joining an outstanding scientific community filled with the brightest, curious and a diverse set of minds?

About Our Cambridge UK Oncology Hub

The role is based at the Cambridge Biomedical Campus; combining world-class biomedical research, patient care and education on a single site location in the heart of Cambridge. This new purpose-built site brings together the company’s research and development activity in an innovative strategic R&D center and global corporate headquarters. The Discover Centre (DISC) was designed with the open architecture reflecting AstraZeneca’s collaborative approach to research. Open laboratories and transparent glass walls will enable new ways of working across teams, whilst a central courtyard will put science on full display.

Innovate and Push the Boundaries of Science in Oncology R&D

Join a dedicated Oncology team that’s growing fast and building a track record of success. Our groundbreaking approach is identifying and treating patients earlier, focusing on early stage cancer trials and listening and evolving based on their needs. As a team we are deeply committed to transforming the lives of patients living with cancer – with the ultimate aim of eliminating cancer as a cause of death. There’s no better place to make an impact – here we are uniquely placed with the funding, the ambition and the bravery to make it happen.

Main Responsibilities

You will provide in vitro support and scientific input for activities within the Early Oncology, Clinical Immuno-Oncology (IO) group at AstraZeneca, Cambridge. You will apply your passion and deep hands-on expertise in IO to lead activities to further elucidate the mechanism of action of IO agents already being tested in clinical trials. This position will provide the opportunity to dissect and explore novel preclinical biology, to collaborate closely with cross functional teams, to see your ideas influence clinical strategies and to present your findings at international conferences and in high quality/high impact peer reviewed journals.

Key responsibilities include:

• This will be a laboratory-based position. You will be responsible for conducting in vitro hands on experimental work around clinical investigatory IO agents: identifying the most relevant line of inquiry, developing and executing experiments to address key questions arising from clinical trials and/or affiliated with IO candidates currently being evaluated in clinical trials.
• Using your knowledge of IO, with an emphasis on the tumor immune-environment and T cell biology, to problem solve and establish innovative approaches to fuel understanding of candidate drug activities & potential combination partners.
• Compile & present pertinent findings to cross-functional global teams in a timely manner.
• Contribute to the preparation of scientific publications (posters & manuscripts) for external communication in addition to supporting documents associated with regulatory submissions.
• Ability to be agile in thought and research development, and demonstrate strength in independent research while working effectively in a collaborative setting.

Essential Requirements

This laboratory based position within the AstraZeneca organization requires an experienced oncology research scientist whose qualities and experience include the following:

• A PhD or equivalent experience in immuno-oncology, cancer biology or immunology
• Ability to implement approaches to the therapeutic manipulation of the immune system in oncology settings
• Strong hands-on skills in basic biochemical and immunological methods including multi-color flow cytometry (FACS), ELISA/multiplex immune-assays, primary human immune cell isolation and culturing, immune cell functional assays (e.g cytotoxicity and proliferation assays, live imaging using IncuCyte)
• Strong interpersonal, influencing, negotiating and collaboration skills together with evidence of having used these to support problem solving and delivery in a team-oriented, collaborative environment
• Excellent organizational and communication skills
• Ability to work in a fast paced environment as a team player, plan and meet timelines
• Proven track record of success in your research, and experience preparing written scientific reports (e.g., manuscripts) and oral presentations to broad and diverse audiences

Desirable Requirements

• Experience working with T-cell engagers, immune checkpoint therapies and/or antibody drug conjugates
• Experience with spectral flow cytometry

So, what’s next?

Are you already envisioning yourself joining our team? Good, because we can’t wait to hear from you!

Closing date for applications: 12 November 2024

Date Posted

Closing Date