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Intern, Discovery Preparation and Humanization, Antibody Discovery

Remote:

Full Remote

Contract:

Full time

Experience:

Entry-level / graduate

Work from:

Netherlands

Offer summary

Qualifications:

MSc student in relevant field, Knowledge of protein engineering preferred, Familiarity with SPR and ITC preferred.

Key responsabilities:

Design oligomeric protein targets
Develop binding assays and affinity measurements
Critically assess binding assay results
Communicate findings clearly to the team
Organize and document results methodically

Genmab Biotech: Biology + Technology Large https://www.genmab.com

1001 - 5000 Employees

See more Genmab offers

Job description

At Genmab, we’re committed to building extra[not]ordinary futures together, by developing antibody products and pioneering, knock-your-socks-off therapies that change the lives of patients and the future of cancer treatment and serious diseases. From our people who are caring, candid, and impact-driven to our business, which is innovative and rooted in science, we believe that being proudly unique, determined to be our best, and authentic is essential to fulfilling our purpose.

Role
Within the Discovery Preparation & Humanization team we are offering an internship or graduation project for an enthusiastic MSc student. The candidate will join our team in Utrecht for 7–9 months to conduct scientific research on Genmab's state-of-the-art antibody products and formats and therefore contribute to improving the lives of cancer patients!

Project

Antibodies are crucial tools in the development of targeted therapies, and Genmab’s innovative antibody formats continuously lead the way to new and innovative treatments for patients. Many therapeutic antibody targets naturally form multimers on the cell surface in order to induce efficient and selective signaling. Detailed characterization of the binding and signaling behavior of the antibody to its target using in vitro assays is crucial to increase understanding and drive successful development of new products. It is important to understand the behavior of protein targets that have the potential to form dimers or oligomers within the conditions of these in vitro experiments, and to study the effect they have on the outcome of the characterization and screening studies.

In this internship, the focus will be on producing and characterizing oligomeric protein targets. Specifically, the intern will work with engineered protein targets that exist in specific oligomeric states, helping to dissect the impact of these states on antibody binding affinity and behavior using biophysical methods including Surface Plasmon Resonance (SPR) and Isothermal Titration Calorimetry (ITC). The project will be carried out in close collaboration with the Functional Characterization & Bioassays team in the CMC department, providing the intern with hands-on experience in protein design, production, and biophysical characterization.

By developing oligomeric protein targets and benchmarking their in vitro behavior, you will contribute to a better understanding of how the oligomeric state of a target influences antibody binding. This knowledge is expected to improve the screening and characterization of therapeutic antibodies and enable more efficient mapping of antibody binding characteristics.

Responsibilities

You design proteins that constitutively exist in a certain oligomeric state using protein engineering techniques and you support successful production and purification of these constructs.
You develop binding assays and perform affinity measurements using SPR and ITC.
You critically assess the quality and outcome of binding assays and provide the team with detailed molecular hypotheses underpinning the observed behavior.
You communicate results clearly to the rest of the team or department. 
You work in the lab in an organized manner and strive to consistently generate good results. 
You document results in an organized and concise manner in the Electronic Lab Notebook (ELN).

Requirements

You are currently connected to a Dutch university and pursuing a Master's degree in a relevant area, e.g. biomedical sciences or biomedical engineering, molecular biology, life sciences, immunology, or similar.
Knowledge and understanding of protein engineering is a pre.
Knowledge and understanding of biophysical techniques such as ITC, SPR and BLI is a pre.
Ability to work successfully in a fast-paced environment in collaboration with a diverse group of scientists and other stakeholders.
Ability to be proactive, enthusiastic and goal oriented.
Strong communication skills in English, both oral and written.

About You

You are passionate about our purpose and genuinely care about our mission to transform the lives of patients through innovative cancer treatment
You bring rigor and excellence to all that you do. You are a fierce believer in our rooted-in-science approach to problem-solving
You are a generous collaborator who can work in teams with diverse backgrounds
You are determined to do and be your best and take pride in enabling the best work of others on the team
You are not afraid to grapple with the unknown and be innovative
You have experience working in a fast-growing, dynamic company (or a strong desire to)
You work hard and are not afraid to have a little fun while you do so

Locations

Genmab leverages the effectiveness of an agile working environment, when possible, for the betterment of employee work-life balance. Our offices are designed as open, community-based spaces that work to connect employees while being immersed in our state-of-the-art laboratories. Whether you’re in one of our collaboratively designed office spaces or working remotely, we thrive on connecting with each other to innovate.

About Genmab

Genmab is an international biotechnology company with a core purpose guiding its unstoppable team to strive towards improving the lives of patients through innovative and differentiated antibody therapeutics. For more than 20 years, its passionate, innovative and collaborative team has invented next-generation antibody technology platforms and leveraged translational research and data sciences, which has resulted in a proprietary pipeline including bispecific T-cell engagers, next-generation immune checkpoint modulators, effector function enhanced antibodies and antibody-drug conjugates. To help develop and deliver novel antibody therapies to patients, Genmab has formed 20+ strategic partnerships with biotechnology and pharmaceutical companies. By 2030, Genmab’s vision is to transform the lives of people with cancer and other serious diseases with Knock-Your-Socks-Off (KYSO™) antibody medicines.

Established in 1999, Genmab is headquartered in Copenhagen, Denmark with locations in Utrecht, the Netherlands, Princeton, New Jersey, U.S. and Tokyo, Japan.

Our commitment to diversity, equity, and inclusion

We are committed to fostering workplace diversity at all levels of the company and we believe it is essential for our continued success. No applicant shall be discriminated against or treated unfairly because of their race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), national origin, age, disability, or genetic information. Learn more about our commitments on our website.

Genmab is committed to protecting your personal data and privacy. Please see our privacy policy for handling your data in connection with your application on our website Job Applicant Privacy Notice (genmab.com).

Please note that if you are applying for a position in the Netherlands, Genmab’s policy for all permanently budgeted hires in NL is initially to offer a fixed-term employment contract for a year, if the employee performs well and if the business conditions do not change, renewal for an indefinite term may be considered after the fixed-term employment contract.