Principal Scientist, DMPK

The Perfect Addition to Our Team

You are a highly motivated, collaborative, and innovative Drug Metabolism and Pharmacokinetics expert with experience driving preclinical DMPK activities. We have a diverse pipeline and as such you should have experience across both small and large molecules and have hands on experience leading the design, analysis, and interpretation of preclinical in vitro and in vivo studies. You are an exceptional communicator and a natural collaborator who is excited about the opportunity to contribute to this function and work closely with cross functional leaders.

The Opportunity

The ideal candidate will serve as a subject matter expert working within the DMPK team to drive the DMPK strategy across all designated programs and pipelines. They will have the opportunity to design, manage, and execute DMPK deliverables, and will be responsible for analyzing, interpreting, and authoring/reviewing ADME and PK/PD reports.

Responsibilities

• Lead all PK- and ADME-related efforts for designated program(s).
• Communicate and present relevant information across all areas of the organization, regardless of level.
• Select and manage PK/TK, PK/PD, and ADME CROs.
• Author and review PK/TK, PK/PD, and ADME reports.
• Author and review relevant PK/TK, PK/PD, and ADME sections of regulatory submission documents (e.g. investigational new drug (IND), investigator brochure (IB), clinical trial application (CTA), etc)
• Review associated reports, including clinical, toxicology, pharmacology, and bioanalysis.
• Collaborate with clinical teams, including pharmacology, biomarkers, development, and operations.
• Collaborate with non-clinical development teams, including toxicology and bioanalysis
• Collaborate with discovery teams to guide future programs and better understand mechanisms of action.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

• Humanity - We genuinely care about patients and about one another.
• Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
• Creativity - We are creative problem solvers.
• Collaboration - We are more than the sum of our parts.
• Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

• PhD in pharmacology or similar field with 8+ years of DMPK experience in an industry setting or a MS with 12+ years of relevant experience
• Expertise with ADME studies and assays, with a proven track record of strategizing and troubleshooting based upon raw data
• Vendor Management experience, specifically managing CROs
• Additional experience with other aspects of ADME, bioanalytical techniques, PK/PD, toxicokinetics, pre-clinical PK/PD modeling, and translational biology are strongly preferred
• Experience with oligonucleotide-based modalities
• Experience authoring and reviewing DMPK-related reports and regulatory documents for health authority submissions is highly desirable
• You should be naturally collaborative and a strong communicator, and let’s not forget the ability to multi-task effectively and work within aggressive timelines– these are key to being successful in Entrada’s fast paced environment
• This is a US based remote position, with preference given to local New England based candidates. This role will require minimum quarterly travel to the Entrada Therapeutics Headquarters located in Boston, MA. #LI-Remote