Principal Scientist, Formulation Development

Location:  This position may be performed remotely, but requires the flexibility and willingness to travel as needed.

The Opportunity

We're looking for a Formulation Scientist to lead drug product development from early discovery through late-stage clinical trials. This role is key to translating promising compounds into high-quality, scalable drug products—supporting everything from preclinical formulation to manufacturing clinical supplies. You'll apply your expertise in formulation development, material characterization, and process scale-up, while also managing relationships with CDMOs to keep things moving smoothly. The ideal candidate combines strong technical skills with curiosity, ownership, and a collaborative mindset—and is excited to work across teams to help bring new therapies to patients. 

Primary Responsibilities

• Ability to represent Formulation on CMC teams and Pharmaceutical Development in multidisciplinary project teams, work collaboratively to ensure project progression, and communicate Formulation/Pharmaceutical Development strategy and related challenges.   
• Plan, design, and supervise the execution, and interpret laboratory experiments to properly characterize novel drug candidates (small molecules and/or ASO).   
• Apply formulation and manufacturing principles, theories and techniques to product development and develop the best possible phase appropriate formulations and manufacturing processes.  
• Work closely with drug discovery teams to ensure timely and high-quality support for preclinical studies.  
• Author technical reports and CMC sections of the regulatory dossiers (INDs, IMPDs, and NDAs etc.).    
• Manage the activities of formulation scientists at CDMOs focused on formulation and manufacturing process development. 
• Work effectively with CDMOs by providing technical oversight to ensure that Praxis’s formulation development and clinical manufacturing needs are met.   

Qualifications and Key Success Factors

• BS, MS, or PhD in pharmaceutical sciences, chemical or biochemical engineering, chemistry or related scientific field and 7+ years (12+ years for BS/MS) of industrial experience.   
• Strong fundamental understanding of physicochemical and biopharmaceutical properties and their importance in formulation design.  
• Strong communication, project management, and interpersonal skills.   
• Effective and innovative problem-solving skills along with the ability to bring together colleagues across functions. 
• Demonstrates voracious intellectual curiosity, innovation and creative problem solving with an entrepreneurial spirit; can thrive in an agile environment. 
• Ability to think critically with a keen sense of urgency and demonstrated problem solving abilities. 
• Self-motivated, able to influence and guide the work of other team members, and contribute to a productive and collaborative team environment.0 
• Highly organized and detail-oriented with a passion to deliver quality results 
• Comfortable with independently making decisions and communicating in a direct fashion.  
• Approaches his/her work with high levels of professionalism, integrity, and personal confidence.    

Compensation & Benefits

At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive.  This includes 99% of the premium paid for medical, dental and vision plans.  We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future?  We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP.  We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns.  Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring.  We aim high, collaborate hard, and produce results.  Let’s achieve the impossible together! 

To round out our world-class total rewards package, we provide annualized base salary compensation in the range listed below.  Final salary range may be modified commensurate with job level, education, and experience.