Principal Engineer

We are Local Infusion.

Local Infusion is a venture-backed healthcare company shaping the way care is delivered to patients with chronic autoimmune disease on specialty infusion medications. Our focus on patient experience, technology, and clinical integration allows us to deliver a differentiated care model that leads to lower costs for patients and enhanced outcomes. Through a blend of patient-centered design and a people-first team culture, Local Infusion puts the "local feel" of community, comfort, and connection back into the patient and provider experience. At our care centers, all patients and our team can feel truly supported, every step of the way.

What We’re About

We’re a team of innovators, clinicians, and technologists on a mission to improve outcomes for patients, save time for physicians, and make infusion therapy more affordable for everyone involved. Our mission is to transform the infusion care industry, because patients deserve better.

• Ownership—Takes initiative, being accountable and caring about the outcome

• Excellence—Do what it takes to raise the bar, being an example for our colleagues, patients and partners

• Curious & Inquisitive— Always seek to gather information and knowledge, and understand the way 

• Find A Way— There will be obstacles, but we find a way, even when there isn’t a defined road forward

• It’s a Marathon, not a Sprint - We have large problems to solve, and they won’t be solved overnight. We are persistent every day. 

• Urgent — We move quickly and with purpose. Patients are waiting, and our work matters.

We’re looking for a Principal Engineer to take full technical ownership of our product roadmap and systems architecture.

As a Principal Engineer at Local Infusion, you’ll play a mission-critical role in building scalable, secure, and reliable systems that power our core operations, including our Virtual Infusion Guide platform and other proprietary technologies. You’ll collaborate cross-functionally with Product, Operations, and external engineering vendors to bring high-impact initiatives to life and position our infrastructure for long-term growth. This is an opportunity to shape the future of healthcare delivery while working with cutting-edge technologies and meaningful real-world data.

In this role, you will:

• Own the technical roadmap and platform architecture to ensure scalability, security, and reliability

• Drive roadmap execution by partnering with Product to define technical milestones and lead end-to-end delivery

• Lead AI & automation initiatives, integrating third-party services and building in-house tools that streamline business processes

• Write and review code, establish engineering best practices, and guide system design standards

• Collaborate cross-functionally with internal teams and external development partners as a technical leader and mentor

• Manage and maintain core systems, including our CRM, EHR, RCM tools, and data infrastructure

• Plan for scale, proactively resolving performance bottlenecks, tech debt, and system constraints

• Oversee vendor performance, evaluating engineering consultants and ensuring quality delivery across all teams

Here’s what we’re looking for:

• 8–10+ years of full-stack engineering experience

• Deep backend experience with Node.js, Python, or Go

• Frontend expertise with frameworks like React or Vue

• Proven success leading architecture in production environments at scale

• Strong API design skills and experience building secure, distributed microservices

• Experience with healthcare systems—HIPAA, HL7, FHIR, EHRs, and payer APIs

• Hands-on experience integrating AI/ML (e.g., LLMs, NLP, document automation, RAG systems)

• Familiarity with DevOps tools, CI/CD workflows, IaC, and observability (Azure preferred)

• Excellent communication skills across technical and non-technical teams

Bonus Points For:

• Experience at fast-moving startups

• Familiarity with tools like LangChain, Pinecone, or custom RAG pipelines

The Local Infusion Way

We’re an ambitious and respectful team united by our mission to reshape specialty infusion care. We believe in doing great work while also taking care of ourselves—our people are encouraged to invest in their lives outside of work, too.

As part of our team, full-time employees get:

• Medical, dental, and vision insurance

• Short- and long-term disability coverage

• Matching 401(k)

• 15 days PTO—and we want you to take it!

• Competitive paid parental leave and flexible return-to-work policy

Local Infusion is an Equal Employment Opportunity (EEO) Employer.

We fundamentally believe that a more diverse and inclusive team leads to a stronger company better equipped to achieve our vision.